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Search for "wound healing" in Full Text gives 12 result(s) in Beilstein Journal of Organic Chemistry.
Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum
Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47
- ]. Pterolobium macropterum Kurz is a woody climbing shrub that is mainly distributed in the northern Thailand. Its roots are used in the medicinal plant therapy to treat toothache, fever, and to promote wound healing [11]. Previous phytochemical investigations of P. macropterum have revealed that this plant is a
Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing
Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171
- solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review
- implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels. Keywords: 3D-bioprinting; cryogels; drug delivery; injectable cryogel; macroporous hydrogel; wound healing
- ][6]. Here we discuss the preparation of cryogels, their properties and applications, focussing on recent reports of cryogels in emerging applications, including bioprinting, injectable cryogels, drug delivery, and wound healing, as investigations in these key areas have intensified in recent years
Progress and challenges in the synthesis of sequence controlled polysaccharides
Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129
Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A
Beilstein J. Org. Chem. 2019, 15, 2958–2965, doi:10.3762/bjoc.15.291
- antibacterical [4], antifungal [5][6], anticancer [7], antioxidant [8], anti-HIV [9], antiulcer, immunostimulator [10], anti-inflammatory [11], as well as biocidal [12], wound-healing [13], and immune-stimulatory activities [14]. For instance, flavoxate [15][16] is a chromone derivative that was employed as an
Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents
Beilstein J. Org. Chem. 2018, 14, 3059–3069, doi:10.3762/bjoc.14.284
- effective than the clinically used antibiotic tobramycin in eradicating biofilms. Although cisplatin is highly toxic for intravenous applications, we showed that it has low toxicity when applied topically to wounds, as 25 mM (0.75 mg mL−1) did not have adverse effect on wound healing. This meant that higher
- 200× and tabulated under % of dead macrophages. Experiments were conducted in triplicate, and the results are shown as the mean ± s.d. Rabbit corneal wound healing model New Zealand White Rabbits (n = 4, weighing 2 to 3 kg) purchased from National University of Singapore, were used for this study. All
- disclosure of wound on the ocular surface [24][25]. Residual wound area (pixel square) was measured during the wound healing process by Image-J 1.44o version. Mann-Whitney U Test was employed to determine if a difference in re-epithelialization existed among the different groups by using GraphPad Prism 6.02
Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells
Beilstein J. Org. Chem. 2018, 14, 2580–2588, doi:10.3762/bjoc.14.235
- cells treated with P. aeruginosa quorum-sensing (QS) molecules, in order to elucidate their role in the occurrence of tissue damages, in which endothelial cells are involved, such as: wound healing, transepithelial migration of neutrophils, lung inflammation and permeability. Also, we highlighted the
Investigation of the electrophilic reactivity of the biologically active marine sesquiterpenoid onchidal and model compounds
Beilstein J. Org. Chem. 2018, 14, 2229–2235, doi:10.3762/bjoc.14.197
- green alga Caulerpa taxifolia, exhibits antiproliferative activities as well as wound healing abilities with the latter resulting from rapid transformation to the highly reactive 1,4-dialdehyde, oxytoxin 2 (4) [4][5][6]. Oxytoxin 2 (4) is itself a natural product, produced by the mollusc Oxynoe olivacea
Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide
Beilstein J. Org. Chem. 2015, 11, 1352–1359, doi:10.3762/bjoc.11.145
- stable hydrogel, which increases the biostability of 8. Meanwhile, 5, 8, and their mixture show excellent cell compatibility, which is a basic requirement for multi-application in vivo (e.g., wound healing [45]). This work provides a new approach to develop biocompatible soft materials. Experimental
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87
- involved in processes like wound healing and the bone regeneration [50][51]. BMP-2, which is locally secreted by skeletal and extraskeletal tissues, is part of the complex bone tissue consisting of different cell types and mineralized ECM. The interplay of these bone-matrix-derived growth factors with
Synthesis of a hexasaccharide partial sequence of hyaluronan for click chemistry and more
Beilstein J. Org. Chem. 2015, 11, 604–607, doi:10.3762/bjoc.11.67
- ]. Despite its simple structure HA can trigger many signaling pathways depending on its fragments' size, thus representing an interesting target in pharmacotherapy. It is involved in tissue repair and wound healing; it serves as space filler, lubricant, protector of the joints and water storage [4]. In
- knowledge can be employed during the development of artificial extracellular matrices for basic research in the field of wound healing in skin and bone injuries. Synthesis of hexasaccharide 10. Conditions: a) TfOH, NIS, 4 Å molecular sieves, DCM, 0 °C to rt; b) 1. Zn, AcOH; 2. Ac2O, pyridine, 50% (over 2
Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view
Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28
- from preexisting ones. Under physiological conditions, angiogenesis is vital for foetal development, tissue regeneration and wound healing. From a pathophysiologic perspective, massive vascular growth or abnormal shape formation promotes many ailments including cancer, inflammation, and eye illnesses
- have also anti-angiogenic properties in vitro and in vivo, further investigations [75] showed that XN repressed both the NF-κB and Akt pathways in endothelial cells, inhibited VEGF-A expression in a wound-healing assay, and exhibited interference in the angiogenic process. The first complete synthesis
An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells
Beilstein J. Org. Chem. 2012, 8, 787–803, doi:10.3762/bjoc.8.89
- cells. In wound-healing assays WM-266-4 cells very rapidly closed the wounds but were never as dense as WM-115 cells upon confluence. We therefore only used WM-115 cells for adhesion assays. These properties may point to high motility of a metastasis-derived cell line. Our earlier results had shown
- number of adherent cells relative to the 5 × 104 cells/well were calculated and related to the control incubations without test compounds. Standard deviations were calculated according to Bishop [54], taking the SD of the control into account. Cell migration (wound healing) assay: Intact cell monolayers
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